Serotonin Transporter Genotype Affects Serotonin 5-HT1A Binding in Primates
نویسندگان
چکیده
منابع مشابه
Serotonin transporter genotype affects serotonin 5-HT1A binding in primates.
Disruption of the serotonin system has been implicated in anxiety and depression and a related genetic variation has been identified that may predispose individuals for these illnesses. The relationship of a functional variation of the serotonin transporter promoter gene (5-HTTLPR) on serotonin transporter binding using in vivo imaging techniques have yielded inconsistent findings when comparin...
متن کاملBrief Communications Serotonin Transporter Genotype Affects Serotonin 5-HT1A Binding in Primates
Bradley T. Christian,1,3,5 Dustin W. Wooten,1 Ansel T. Hillmer,1 Dana L. Tudorascu,6 Alexander K. Converse,5 Colleen F. Moore,4 Elizabeth O. Ahlers,5 Todd E. Barnhart,1 Ned H. Kalin,3,4,5 Christina S. Barr,7 and Mary L. Schneider2,4 Departments of 1Medical Physics, 2Kinesiology, 3Psychiatry, and 4Psychology, and 5Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, 6Depart...
متن کاملA functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.
In humans, 5-HT1A receptors are implicated in anxiety and depressive disorders and their treatment. However, the physiological and genetic factors controlling 5-HT1A receptor expression are undetermined in health and disease. In this study, the influence of two genetic factors on 5-HT1A receptor expression in the living human brain was assessed using the 5-HT1A-selective positron emission tomog...
متن کاملSerotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans.
The human serotonin transporter (5-HTT) gene is one of the most extensively studied in psychiatry. A functional polymorphism in the promoter region of the 5-HTT gene (5-HTTLPR) has been associated with several psychiatric disorders as well as anxiety-related personality traits. In search of a mechanistic understanding of the functional implications of 5-HTTLPR, the influence of this polymorphis...
متن کاملSerotonin Transporter Genotype (5-HTTLPR) Predicts Utilitarian Moral Judgments
BACKGROUND The psychological and neurobiological processes underlying moral judgment have been the focus of extensive recent research. Here we show that serotonin transporter (5-HTTLPR) genotype predicts responses to moral dilemmas featuring foreseen harm to an innocent. METHODOLOGY/PRINCIPAL FINDINGS Participants in this study judged the acceptability of actions that would unintentionally or...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2013
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4182-12.2013